SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
          Under the Securities Exchange Act of 1934 (Amendment No. 6)*


                                  BioTime, Inc.
 ...............................................................................
                                (Name of Issuer)

                           Common Shares, no par value
 ...............................................................................
                         (Title of Class of Securities)

                                    09066L105
 ...............................................................................
                                 (CUSIP Number)

                          Paul Segall and Judith Segall
          935 Pardee Street, Berkeley, California 94710; (510) 845-9535
 ...............................................................................
(Name, Address and Telephone Number of Person Authorized to Receive Notices 
 and Communications)

                                  May 10, 1999
 ...............................................................................
              (Date of Event which Requires Filing this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of ss.ss.240.13d-1(e), 240.13d-1(f), or 240.13d-1(g), check the
following box [ ].

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule,  including all exhibits.  See  ss.240.13d-7(b) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.


CUSIP No. 09066L105 1) Names of Reporting Persons S.S. or I.R.S. Identification Nos. of Above Persons Paul Segall 2) Check the Appropriate Box if a Member of a Group (See Instructions) (a) [ ] (b) [ ] 3) SEC Use Only 4) Source of Funds (See Instructions) PF; OO 5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) [ ] 6) Citizenship or Place of Organization U.S.A. 7) Sole Voting Power Number of 543,245 Shares Beneficially 8) Shared Voting Power Owned by 0 Each Reporting 9) Sole Dispositive Power Person With 543,245 10) Shared Dispositive Power 0 11) Aggregate Amount Beneficially Owned by Each Reporting Person 745,408 12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) [ ] 13) Percent of Class Represented by Amount in Row (11) 6.9% 14) Type of Reporting Person (See Instructions) IN Page 2 of 6 Pages

CUSIP No. 09066L105 1) Names of Reporting Persons S.S. or I.R.S. Identification Nos. of Above Persons Judith Segall 2) Check the Appropriate Box if a Member of a Group (See Instructions) (a) [ ] (b) [ ] 3) SEC Use Only 4) Source of Funds (See Instructions) PF; OO 5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) [ ] 6) Citizenship or Place of Organization U.S.A. 7) Sole Voting Power Number of 202,163 Shares Beneficially 8) Shared Voting Power Owned by 0 Each Reporting 9) Sole Dispositive Power Person With 202,163 10) Shared Dispositive Power 0 11) Aggregate Amount Beneficially Owned by Each Reporting Person 745,408 12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) [ ] 13) Percent of Class Represented by Amount in Row (11) 6.9% 14) Type of Reporting Person (See Instructions) IN Page 3 of 6 Pages

Item 1. Security and Issuer The class of equity securities to which this schedule relates is Common Shares, no par value (the "Common Shares"), of BioTime, Inc., a California corporation (the "Company"). The Company has its principal executive offices at 935 Pardee Street, Berkeley, California 94710. This schedule is being filed pursuant to Section 13(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act") and the rules and regulations promulgated thereunder. Item 2. Identity and Background (a) The names of the persons filing this schedule are Paul Segall and Judith Segall. (b) The business address of Paul Segall and Judith Segall is 935 Pardee Street, Berkeley, California 94710. (c) Paul Segall is currently the Chairman and Chief Executive Officer of BioTime, Inc., 935 Pardee Street, Berkeley, California 94710. Judith Segall is currently the Vice President and Secretary of BioTime, Inc. (d) Paul Segall and Judith Segall have not been convicted during the last five years in a criminal proceeding, excluding traffic violations or similar misdemeanors. (e) Neither Paul Segall nor Judith Segall has been a party during the last five years to any civil roceeding of a judicial or administrative body of competent jurisdiction, and neither of them has, as a result of such a proceeding, been subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws. (f) Both Paul Segall and Judith Segall are citizens of the United States of America. Item 3. Source and Amount of Funds or Other Consideration Paul Segall and Judith Segall have each executed a Customer Agreement and Control or Restricted (Rule 144) Stock Borrower's Agreement (collectively, "Customer Agreement") with Donaldson, Lufkin & Jenrette Securities Corporation ("DLJ") pursuant to which they may borrow funds from time time. On or about May 10, 1999, Mr. and Mrs. Segall borrowed $1,133,477.71 from DLJ under the terms of their Customer Agreement and used the proceeds to repay certain margin loans to NationsBank Montgomery Securities. Page 4 of 6 Pages

Mr. and Mrs. Segall have pledged a portion of their Common Shares as collateral for such loans. A copy of the aforesaid Customer Agreement is filed as an Exhibit to this Schedule 13D and is incorporated herein by reference. Item 7. Material to Be Filed as Exhibits (a) Customer Agreement with Donald, Lufkin & Jenrette Securities Corporation (b) Control or Restricted (Rule 144) Stock Borrower's Agreement Page 5 of 6 Pages

Signature After reasonable inquiry and to the best of our knowledge we certify that the information set forth in the statement is true, complete and correct. /s/ Paul Segall Dated: May 12, 1999 ____________________________________ Paul Segall /s/ Judith Segall Dated: May 12, 1999 ____________________________________ Judith Segall Page 6 of 6 Pages




                          DONALDSON, LUFKIN & JENRETTE
                             Securities Corporation
                    277 Park Avenue, New York, New York 10172


                               CUSTOMER AGREEMENT


         In consideration of your accepting and carrying for the undersigned one
or more accounts, the undersigned hereby consents and agrees that:

APPLICABLE RULES AND REGULATIONS

1. All  transactions for the undersigned  shall be subject to the  constitution,
rules,  regulations,  customs  and  usages of the  exchange  or  market  and its
clearing  house,  if any, where  executed by you or your agents,  including your
subsidiaries and affiliates.


DEFINITION

2. For purposes of this agreement "securities,  commodities and other property,"
as used  herein  shall  include,  but not be limited to money,  securities,  and
commodities  of every kind and nature and all  contracts  and  options  relating
thereto, whether for present or future delivery.

LIEN

3. All securities, commodities and other property now or hereafter held, carried
or maintained by you in your  possession and control for any purpose,  in or for
any of the  accounts of the  undersigned,  now or  hereafter  opened,  including
accounts in which the  undersigned  may have an interest,  shall be subject to a
lien for the  discharge of all the  indebtedness  and other  obligations  of the
undersigned to you, and are to be held by you as security for the payment of any
liability or indebtedness of the undersigned to you in any of said accounts. You
shall have the right to transfer  securities,  commodities and other property so
held by you from or to any other of the accounts of the undersigned  whenever in
your judgment you consider such a transfer  necessary  for your  protection.  In
enforcing your lien, you shall have the discretion to determine which securities
and property are to be sold and which contracts are to be closed.

LIQUIDATION

4. You shall have the right, in accordance with your general policies  regarding
your  margin  maintenance  requirements,  as such may be  modified,  amended  or
supplemented  from  time to time,  or if, in your  discretion  you  consider  it
necessary for your protection to require additional  collateral at an earlier or


                                       1

later point in time than called for by said general policies, or in the event that a petition in bankruptcy, or for appointment of a received is filed by or against the undersigned, or an attachment is levied against the accounts of the undersigned, or in the event of the death of the undersigned, to sell any or all securities, commodities and other property in the accounts of the undersigned with you, whether carried individually or jointly with others, to buy any or all securities, commodities and other property which may be short in such accounts, to cancel any open orders and to close any or all outstanding contracts, all without demand for margin or additional margin, notice of sale or purchase or other notice to advertisement. Any such sales or purchases may be made at your discretion on any exchange or other market where such business is usually transacted, or at public auction or private sale, and you may be the purchasers for your own account. It being understood that a prior demand, or call, or prior notice of the time and place of such sale or purchase shall not be considered a waiver of your right to sell or buy without demand or notice as herein provided. PAYMENT OF INDEBTEDNESS UPON DEMAND 5. The undersigned shall at all times be liable for the payment upon demand of any debit balance or other obligations owing in any of the accounts of the undersigned with you and, the undersigned shall be liable to you for any deficiency remaining in any such accounts in the event of the liquidation thereof, in whole or in part, by you or by the undersigned; and, the undersigned shall make payment of such obligations and indebtedness upon demand. LIABILITY FOR COSTS OF COLLECTION 6. The reasonable costs and expenses of collection of the debit balance and any unpaid deficiency in the accounts of the undersigned with you, including, but not limited to, attorney's fees, incurred and payable or paid by you shall be payable to you by the undersigned. PLEDGE OF SECURITIES, COMMODITIES AND OTHER PROPERTY 7. All securities, commodities and other property now or thereafter held, carried or maintained by you in your possession in any of the accounts of the undersigned may be pledged and repledged by you from time to time, without notice to the undersigned, either separately or in common with other such securities, commodities and other property for any amount due in the accounts of the undersigned, or for any greater amount, and you may do so without retaining to your possession or control for delivery a like amount of similar securities, commodities or other property. MARGIN REQUIREMENTS, CREDIT CHARGES AND CREDIT INVESTIGATION 8. The undersigned will at all times maintain such securities, commodities and other property in the accounts of the undersigned for margin purposes as you shall require from time to time and the monthly debit balances or adjusted balances in the accounts of the undersigned with you shall be charged, in accordance with your usual custom, with interest at a rate permitted by the laws 2

of the State of New York. It is understood that the interest charge made to the undersigned's account at the close of a charge period will be added to the opening balance for the next charge period unless paid. You may exchange credit information about the undersigned with others. You may request a credit report on the undersigned and upon request, you will state the name and address of the consumer reporting agency that furnished it. If you extend, update or renew the undersigned's credit, you may request a new credit report without telling the undersigned. PRESUMPTION OF RECEIPT OF COMMUNICATIONS 9. Communications may be sent to the undersigned at the address of the undersigned or at such other address as the undersigned may hereafter give you in writing, and all communications so sent, whether by mail, telegraph, messenger or otherwise, shall be deemed given to the undersigned personally, whether actually received or not. NO NON-INVESTMENT ADVICE 10. The undersigned acknowledges that you will not provide the undersigned with any legal, tax or accounting advice, that your employees are not authorized to give any such advice and that the undersigned will not solicit or rely upon any such advice from you or your employees whether in connection with transactions in or for any of the accounts of the undersigned or otherwise. In making legal, tax or accounting decisions with respect to transactions in or for the accounts of the undersigned or any other matter, the undersigned will consult with and rely upon its own advisors and not you, and you shall have no liability therefor. SCOPE AND TRANSFERABILITY 11. This agreement shall cover individually and collectively all accounts which the undersigned may open or reopen with you, and shall inure to the benefit of your successors whether by merger, consolidation or otherwise, and assigns, and you may transfer the accounts of the undersigned to your successors and assigns, and this agreement shall be binding upon the heirs, executors, administrators, successors and assigns of the undersigned. EXTRAORDINARY EVENTS 12. You shall not be liable for loss caused directly or indirectly by government restrictions, exchange or market rulings, suspension of trading, war, strikes or other conditions beyond your control. 3

REPRESENTATIONS AS TO CAPACITY TO ENTER INTO AGREEMENT 13. The undersigned, if an individual, represents that the undersigned is of full age, that unless otherwise disclosed to you in writing the undersigned is not an employee of any exchange, or of any corporation of which any exchange owns a majority of the capital stock, or of a member firm or member corporation registered on any exchange or of a bank, trust company, insurance company or of any corporations, firm or individual engaged in the business of dealing either as a broker or as principal in securities, bills of exchange acceptances or other forms of commercial paper. The undersigned further represents that no one except the undersigned has an interest in the account or accounts of the undersigned with you. JOINT AND SEVERAL LIABILITY 14. If the undersigned shall consist of more than one individual, their obligations under this agreement shall be joint and several. The undersigned have executed the Joint Account Agreement and made the election required therein. Pursuant to that agreement, you may, but are not required to, accept instructions from either joint party. OPTION TRANSACTIONS 15. If at any time the undersigned shall enter into any transaction for the purchase or resale of an option contract, the undersigned hereby agrees to abide by the rules of any national securities association, registered securities exchange or clearing organization applicable to the trading of option contracts and, acting alone or in concert, will not violate the position or exercise limitation rules of any such association or exchange or of the Option Clearing Corporation or other clearing organization. SEPARABILITY 16. If any provision or condition of this agreement shall be held to be invalid or unenforceable by any court, or regulatory or self-regulatory agency or body, such invalidity or unenforceability shall attach only to such provision or condition. The validity of the remaining provisions and conditions shall not be affected thereby and this agreement shall be carried out as if any such invalid or unenforceable provision or condition were not contained herein. HEADINGS ARE DESCRIPTIVE 17. The heading of each provision hereof is for descriptive purposes only and shall not be deemed to modify or qualify any of the rights or obligations set forth in each such provision. ARBITRATION DISCLOSURES 18. * ARBITRATION IS FINAL AND BINDING ON THE PARTIES. 4

* THE PARTIES ARE WAIVING THEIR RIGHT TO SEEK REMEDIES IN COURT, INCLUDING THE RIGHT TO JURY TRIAL * PRE-ARBITRATION DISCOVERY IS GENERALLY MORE LIMITED THAN AND DIFFERENT FROM COURT PROCEEDINGS. * THE ARBITRATOR'S AWARD IS NOT REQUIRED TO INCLUDE FACTUAL FINDINGS OR LEGAL REASONING AND ANY PARTY'S RIGHT TO APPEAL OR TO SEEK MODIFICATION OF RULINGS BY THE ARBITRATORS IS STRICTLY LIMITED. * THE PANEL OF ARBITRATORS WILL TYPICALLY INCLUDE A MINORITY OF ARBITRATORS WHO WERE OR ARE AFFILIATED WITH THE SECURITIES INDUSTRY. AGREEMENT TO ARBITRATE CONTROVERSIES 19. IT IS AGREED THAT ANY CONTROVERSY BETWEEN US ARISING OUT OF YOUR BUSINESS OR THIS AGREEMENT, SHALL BE SUBMITTED TO ARBITRATION CONDUCTED BEFORE THE NEW YORK STOCK EXCHANGE, INC. OR ANY OTHER NATIONAL SECURITIES EXCHANGE ON WHICH A TRANSACTION GIVING RISE TO THE CLAIM TOOK PLACE (AND ONLY BEFORE SUCH EXCHANGE) OR NASD REGULATION, INC., AS THE UNDERSIGNED MAY ELECT AND IN ACCORDANCE WITH THE RULES OBTAINING OF THE SELECTED ORGANIZATION. ARBITRATION MUST BE COMMENCED BY SERVICE UPON THE OTHER PARTY OF A WRITTEN DEMAND FOR ARBITRATION OR A WRITTEN NOTICE OF INTENTION TO ARBITRATE, THEREIN ELECTING THE ARBITRATION TRIBUNAL. IN THE EVENT THE UNDERSIGNED DOES NOT MAKE SUCH ELECTION WITHIN FIVE (5) DAYS OF SUCH DEMAND OR NOTICE, THEN THE UNDERSIGNED AUTHORIZES YOU TO DO SO ON BEHALF OF THE UNDERSIGNED. NO PERSON SHALL BRING A PUTATIVE OR CERTIFIED CLASS ACTION TO ARBITRATION NOR SEEK TO ENFORCE ANY PRE-DISPUTE ARBITRATION AGREEMENT AGAINST ANY PERSON WHO HAS INITIATED IN COURT A PUTATIVE CLASS ACTION; OR WHO IS A MEMBER OF A PUTATIVE CLASS WHO HAS NOT OPTED OUT OF THE CLASS WITH RESPECT TO ANY CLAIMS ENCOMPASSED BY THE PUTATIVE CLASS ACTION UNTIL: (i) THE CLASS CERTIFICATION IS DENIED; OR (ii) THE CLASS IS DECERTIFIED; OR (iii) THE CUSTOMER IS EXCLUDED FROM THE CLASS BY THE COURT. SUCH FORBEARANCE TO ENFORCE AN AGREEMENT TO ARBITRATE SHALL NOT CONSTITUTE A WAIVER OF ANY RIGHTS UNDER THIS AGREEMENT EXCEPT TO THE EXTENT STATED HEREIN. THE LAWS OF THE STATE OF NEW YORK GOVERN 5

20. THIS AGREEMENT AND ITS ENFORCEMENT SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK WITHOUT GIVING EFFECT TO ITS CONFLICTS OF LAWS PROVISIONS. LOAN CONSENT 21. BY SIGNING THIS AGREEMENT, THE UNDERSIGNED ACKNOWLEDGES THAT SECURITIES NOT FULLY PAID FOR BY THE UNDERSIGNED MAY BE LOANED TO YOU OR LOANED OUT TO OTHERS. THIS AGREEMENT CONTAINS A PRE-DISPUTE ARBITRATION CLAUSE IN PARAGRAPHS 18 AND 19 ON THIS PAGE. I ACKNOWLEDGE RECEIVING A COPY OF THIS AGREEMENT. SIGNATURES (If a Corporation, Partnership or Other Entity) (If Individuals) /s/ Paul Segall - ------------------------------------- ------------------------------ Name of Entity ------------------------------ (Second Party, If Joint Account) By___________________________________ Title__________________________________ SEAL DATED_________________ACCOUNT NO.______________________ 6


                     CONTROL OR RESTRICTED (RULE 144) STOCK
                              BORROWER'S AGREEMENT



         In consideration  of any margin credit extended by Donaldson,  Lufkin &
Jenrette Securities  Corporation ("DLJ") to the undersigned on 179,665 shares of
the common stock of BioTime,  Inc. owned by the  undersigned  and pledged to DLJ
(the "Shares"), the undersigned agrees, represents and warrants as follows:


         1.  The  Shares  are  fully  paid  for  and  the   undersigned  is  the
unconditional  beneficial  owner of the Shares,  free and clear of any  security
interest,  claim  or  charge.  The  Shares  are  registered  in the  name of the
undersigned,  no other  person or entity has an  interest  in the Shares and the
undersigned has fully right, power and authority to sell,  pledge,  transfer and
deliver the Shares.


         2. The  Shares or any other  such  shares  owned or  controlled  by the
undersigned  (i)  have  not  been  assigned,   transferred,   donated,  pledged,
encumbered  or the  subject of a put or call  option by the  undersigned  or any
other person or entity (ii) will be deposited in the account of the  undersigned
with DLJ in fully  negotiable  form,  and (iii) for the period of the agreement,
will not be sold, assigned,  transferred,  donated,  pledged,  encumbered or the
subject of a put or call option by the undersigned or any other person or entity
without the prior written consent of a principal of DLJ; provided, however, such
requirement shall not apply to sales of the Shares through DLJ, or the pledge of
the Shares to DLJ as provided in the agreement.


         3. All of the Information set forth by the undersigned in the Form 144,
Rule 144 Questionnaire and representation  letter,  copies of which are attached
and made a part hereof,  is accurate and complete and should any change or event
occur  which  would  render  the  information  Inaccurate  or  Incomplete,   the
undersigned will immediately notify DLJ of such change or event.


         4.  The  margin  credit   arrangement   referred  to  herein  shall  be
supplemental  and in addition to all the terms and  conditions  of the  Customer
Agreement between the undersigned and DLJ which the undersigned  acknowledges he
has read, understood, and executed and which remains in full force and effect.


         5. It is understood  that the minimum margin  required to be maintained
by the  undersigned  for the Shares is 40% of the  current  market  value of the
Shares as  determined  on a day by day basis or $3.00 per  share,  whichever  is
greater. It is further understood that such minimum maintenance  requirement may
be changed by DLJ at any time.

                                       1

6. Should it become necessary to sell any of the Shares or to satisfy a margin deficiency, the undersigned agrees fully to cooperate with DLJ, including the furnishing of information and completion of forms and instruments necessary to effect the sale. In addition, DLJ shall be authorized to sign a properly completed Form 144 in the name of and on behalf of the undersigned. Capitalized terms that are used herein but not otherwise defined shall have the meanings ascribed to such terms in Control or Restricted (Rule 144) Stock Borrower's Agreement between the undersigned and DLJ of even date herewith. 7. It is agreed that in the event the undersigned fails to satisfy a margin deficiency, DLJ is hereby authorized to liquidate at it discretion sufficient shares of this security held in the undersigned's account to satisfy the margin deficiency. 8. The undersigned will not take any action that would impair the salability of the Shares or omit to take any action necessary to avoid such impairment. The undersigned further agrees to indemnify and hold harmless DLJ and its officers and employees from any loss, liability, claim, damage or expense, including any legal expense, to which DLJ and its officers and employees may become the subject as a result of any untrue statement or omission in any document furnished to DLJ by the undersigned or breach of this agreement by the undersigned. 9. The failure by DLJ to object to any act or omission on the part of the undersigned which is in contravention of any provision of this agreement, shall not constitute a waiver of any of the rights of DLJ under this agreement or otherwise. 10. The undersigned represents that he has sufficient collateral or cash to meet any margin calls which might result form a margin deficiency or from the subsequent unavailability of Rule 144 and that he will promptly advise DLJ should he become aware of any circumstances indicating that Rule 144 is no longer available with respect to the shares pledged. 11. DLJ agrees that the interest rate to be charged shall be 3.00% above the Pershing Base Lending Rate, as described in the attached "Disclosure Statement." 2

12. This agreement shall remain in full force and effect until it is either (i) terminated by DLJ, or (ii) terminated by the undersigned with the consent of DLJ. However, all representations, warranties and indemnities provided by the undersigned hereunder shall survive the termination of this agreement. /s/Paul Segall ------------------------------- (Signature) Paul Segall ------------------------------- (Name) ------------------------------- (Date) ------------------------------- (Account Number) Joint Account ------------------------------- (Signature) ------------------------------- (Name) ------------------------------- (Date) 3




                          DONALDSON, LUFKIN & JENRETTE
                             Securities Corporation
                    277 Park Avenue, New York, New York 10172


                               CUSTOMER AGREEMENT


         In consideration of your accepting and carrying for the undersigned one
or more accounts, the undersigned hereby consents and agrees that:

APPLICABLE RULES AND REGULATIONS

1. All  transactions for the undersigned  shall be subject to the  constitution,
rules,  regulations,  customs  and  usages of the  exchange  or  market  and its
clearing  house,  if any, where  executed by you or your agents,  including your
subsidiaries and affiliates.


DEFINITION

2. For purposes of this agreement "securities,  commodities and other property,"
as used  herein  shall  include,  but not be limited to money,  securities,  and
commodities  of every kind and nature and all  contracts  and  options  relating
thereto, whether for present or future delivery.

LIEN

3. All securities, commodities and other property now or hereafter held, carried
or maintained by you in your  possession and control for any purpose,  in or for
any of the  accounts of the  undersigned,  now or  hereafter  opened,  including
accounts in which the  undersigned  may have an interest,  shall be subject to a
lien for the  discharge of all the  indebtedness  and other  obligations  of the
undersigned to you, and are to be held by you as security for the payment of any
liability or indebtedness of the undersigned to you in any of said accounts. You
shall have the right to transfer  securities,  commodities and other property so
held by you from or to any other of the accounts of the undersigned  whenever in
your judgment you consider such a transfer  necessary  for your  protection.  In
enforcing your lien, you shall have the discretion to determine which securities
and property are to be sold and which contracts are to be closed.

LIQUIDATION

4. You shall have the right, in accordance with your general policies  regarding
your  margin  maintenance  requirements,  as such may be  modified,  amended  or
supplemented  from  time to time,  or if, in your  discretion  you  consider  it
necessary for your protection to require additional  collateral at an earlier or


                                       1

later point in time than called for by said general policies, or in the event that a petition in bankruptcy, or for appointment of a received is filed by or against the undersigned, or an attachment is levied against the accounts of the undersigned, or in the event of the death of the undersigned, to sell any or all securities, commodities and other property in the accounts of the undersigned with you, whether carried individually or jointly with others, to buy any or all securities, commodities and other property which may be short in such accounts, to cancel any open orders and to close any or all outstanding contracts, all without demand for margin or additional margin, notice of sale or purchase or other notice to advertisement. Any such sales or purchases may be made at your discretion on any exchange or other market where such business is usually transacted, or at public auction or private sale, and you may be the purchasers for your own account. It being understood that a prior demand, or call, or prior notice of the time and place of such sale or purchase shall not be considered a waiver of your right to sell or buy without demand or notice as herein provided. PAYMENT OF INDEBTEDNESS UPON DEMAND 5. The undersigned shall at all times be liable for the payment upon demand of any debit balance or other obligations owing in any of the accounts of the undersigned with you and, the undersigned shall be liable to you for any deficiency remaining in any such accounts in the event of the liquidation thereof, in whole or in part, by you or by the undersigned; and, the undersigned shall make payment of such obligations and indebtedness upon demand. LIABILITY FOR COSTS OF COLLECTION 6. The reasonable costs and expenses of collection of the debit balance and any unpaid deficiency in the accounts of the undersigned with you, including, but not limited to, attorney's fees, incurred and payable or paid by you shall be payable to you by the undersigned. PLEDGE OF SECURITIES, COMMODITIES AND OTHER PROPERTY 7. All securities, commodities and other property now or thereafter held, carried or maintained by you in your possession in any of the accounts of the undersigned may be pledged and repledged by you from time to time, without notice to the undersigned, either separately or in common with other such securities, commodities and other property for any amount due in the accounts of the undersigned, or for any greater amount, and you may do so without retaining to your possession or control for delivery a like amount of similar securities, commodities or other property. MARGIN REQUIREMENTS, CREDIT CHARGES AND CREDIT INVESTIGATION 8. The undersigned will at all times maintain such securities, commodities and other property in the accounts of the undersigned for margin purposes as you shall require from time to time and the monthly debit balances or adjusted balances in the accounts of the undersigned with you shall be charged, in accordance with your usual custom, with interest at a rate permitted by the laws 2

of the State of New York. It is understood that the interest charge made to the undersigned's account at the close of a charge period will be added to the opening balance for the next charge period unless paid. You may exchange credit information about the undersigned with others. You may request a credit report on the undersigned and upon request, you will state the name and address of the consumer reporting agency that furnished it. If you extend, update or renew the undersigned's credit, you may request a new credit report without telling the undersigned. PRESUMPTION OF RECEIPT OF COMMUNICATIONS 9. Communications may be sent to the undersigned at the address of the undersigned or at such other address as the undersigned may hereafter give you in writing, and all communications so sent, whether by mail, telegraph, messenger or otherwise, shall be deemed given to the undersigned personally, whether actually received or not. NO NON-INVESTMENT ADVICE 10. The undersigned acknowledges that you will not provide the undersigned with any legal, tax or accounting advice, that your employees are not authorized to give any such advice and that the undersigned will not solicit or rely upon any such advice from you or your employees whether in connection with transactions in or for any of the accounts of the undersigned or otherwise. In making legal, tax or accounting decisions with respect to transactions in or for the accounts of the undersigned or any other matter, the undersigned will consult with and rely upon its own advisors and not you, and you shall have no liability therefor. SCOPE AND TRANSFERABILITY 11. This agreement shall cover individually and collectively all accounts which the undersigned may open or reopen with you, and shall inure to the benefit of your successors whether by merger, consolidation or otherwise, and assigns, and you may transfer the accounts of the undersigned to your successors and assigns, and this agreement shall be binding upon the heirs, executors, administrators, successors and assigns of the undersigned. EXTRAORDINARY EVENTS 12. You shall not be liable for loss caused directly or indirectly by government restrictions, exchange or market rulings, suspension of trading, war, strikes or other conditions beyond your control. 3

REPRESENTATIONS AS TO CAPACITY TO ENTER INTO AGREEMENT 13. The undersigned, if an individual, represents that the undersigned is of full age, that unless otherwise disclosed to you in writing the undersigned is not an employee of any exchange, or of any corporation of which any exchange owns a majority of the capital stock, or of a member firm or member corporation registered on any exchange or of a bank, trust company, insurance company or of any corporations, firm or individual engaged in the business of dealing either as a broker or as principal in securities, bills of exchange acceptances or other forms of commercial paper. The undersigned further represents that no one except the undersigned has an interest in the account or accounts of the undersigned with you. JOINT AND SEVERAL LIABILITY 14. If the undersigned shall consist of more than one individual, their obligations under this agreement shall be joint and several. The undersigned have executed the Joint Account Agreement and made the election required therein. Pursuant to that agreement, you may, but are not required to, accept instructions from either joint party. OPTION TRANSACTIONS 15. If at any time the undersigned shall enter into any transaction for the purchase or resale of an option contract, the undersigned hereby agrees to abide by the rules of any national securities association, registered securities exchange or clearing organization applicable to the trading of option contracts and, acting alone or in concert, will not violate the position or exercise limitation rules of any such association or exchange or of the Option Clearing Corporation or other clearing organization. SEPARABILITY 16. If any provision or condition of this agreement shall be held to be invalid or unenforceable by any court, or regulatory or self-regulatory agency or body, such invalidity or unenforceability shall attach only to such provision or condition. The validity of the remaining provisions and conditions shall not be affected thereby and this agreement shall be carried out as if any such invalid or unenforceable provision or condition were not contained herein. HEADINGS ARE DESCRIPTIVE 17. The heading of each provision hereof is for descriptive purposes only and shall not be deemed to modify or qualify any of the rights or obligations set forth in each such provision. ARBITRATION DISCLOSURES 18. * ARBITRATION IS FINAL AND BINDING ON THE PARTIES. 4

* THE PARTIES ARE WAIVING THEIR RIGHT TO SEEK REMEDIES IN COURT, INCLUDING THE RIGHT TO JURY TRIAL * PRE-ARBITRATION DISCOVERY IS GENERALLY MORE LIMITED THAN AND DIFFERENT FROM COURT PROCEEDINGS. * THE ARBITRATOR'S AWARD IS NOT REQUIRED TO INCLUDE FACTUAL FINDINGS OR LEGAL REASONING AND ANY PARTY'S RIGHT TO APPEAL OR TO SEEK MODIFICATION OF RULINGS BY THE ARBITRATORS IS STRICTLY LIMITED. * THE PANEL OF ARBITRATORS WILL TYPICALLY INCLUDE A MINORITY OF ARBITRATORS WHO WERE OR ARE AFFILIATED WITH THE SECURITIES INDUSTRY. AGREEMENT TO ARBITRATE CONTROVERSIES 19. IT IS AGREED THAT ANY CONTROVERSY BETWEEN US ARISING OUT OF YOUR BUSINESS OR THIS AGREEMENT, SHALL BE SUBMITTED TO ARBITRATION CONDUCTED BEFORE THE NEW YORK STOCK EXCHANGE, INC. OR ANY OTHER NATIONAL SECURITIES EXCHANGE ON WHICH A TRANSACTION GIVING RISE TO THE CLAIM TOOK PLACE (AND ONLY BEFORE SUCH EXCHANGE) OR NASD REGULATION, INC., AS THE UNDERSIGNED MAY ELECT AND IN ACCORDANCE WITH THE RULES OBTAINING OF THE SELECTED ORGANIZATION. ARBITRATION MUST BE COMMENCED BY SERVICE UPON THE OTHER PARTY OF A WRITTEN DEMAND FOR ARBITRATION OR A WRITTEN NOTICE OF INTENTION TO ARBITRATE, THEREIN ELECTING THE ARBITRATION TRIBUNAL. IN THE EVENT THE UNDERSIGNED DOES NOT MAKE SUCH ELECTION WITHIN FIVE (5) DAYS OF SUCH DEMAND OR NOTICE, THEN THE UNDERSIGNED AUTHORIZES YOU TO DO SO ON BEHALF OF THE UNDERSIGNED. NO PERSON SHALL BRING A PUTATIVE OR CERTIFIED CLASS ACTION TO ARBITRATION NOR SEEK TO ENFORCE ANY PRE-DISPUTE ARBITRATION AGREEMENT AGAINST ANY PERSON WHO HAS INITIATED IN COURT A PUTATIVE CLASS ACTION; OR WHO IS A MEMBER OF A PUTATIVE CLASS WHO HAS NOT OPTED OUT OF THE CLASS WITH RESPECT TO ANY CLAIMS ENCOMPASSED BY THE PUTATIVE CLASS ACTION UNTIL: (i) THE CLASS CERTIFICATION IS DENIED; OR (ii) THE CLASS IS DECERTIFIED; OR (iii) THE CUSTOMER IS EXCLUDED FROM THE CLASS BY THE COURT. SUCH FORBEARANCE TO ENFORCE AN AGREEMENT TO ARBITRATE SHALL NOT CONSTITUTE A WAIVER OF ANY RIGHTS UNDER THIS AGREEMENT EXCEPT TO THE EXTENT STATED HEREIN. THE LAWS OF THE STATE OF NEW YORK GOVERN 5

20. THIS AGREEMENT AND ITS ENFORCEMENT SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK WITHOUT GIVING EFFECT TO ITS CONFLICTS OF LAWS PROVISIONS. LOAN CONSENT 21. BY SIGNING THIS AGREEMENT, THE UNDERSIGNED ACKNOWLEDGES THAT SECURITIES NOT FULLY PAID FOR BY THE UNDERSIGNED MAY BE LOANED TO YOU OR LOANED OUT TO OTHERS. THIS AGREEMENT CONTAINS A PRE-DISPUTE ARBITRATION CLAUSE IN PARAGRAPHS 18 AND 19 ON THIS PAGE. I ACKNOWLEDGE RECEIVING A COPY OF THIS AGREEMENT. SIGNATURES (If a Corporation, Partnership or Other Entity) (If Individuals) /s/ Judith Segall - ------------------------------------- ------------------------------ Name of Entity ------------------------------ (Second Party, If Joint Account) By___________________________________ Title__________________________________ SEAL DATED_________________ACCOUNT NO.______________________ 6


                     CONTROL OR RESTRICTED (RULE 144) STOCK
                              BORROWER'S AGREEMENT



         In consideration  of any margin credit extended by Donaldson,  Lufkin &
Jenrette Securities  Corporation ("DLJ") to the undersigned on  47,031 shares of
the common stock of BioTime,  Inc. owned by the  undersigned  and pledged to DLJ
(the "Shares"), the undersigned agrees, represents and warrants as follows:


         1.  The  Shares  are  fully  paid  for  and  the   undersigned  is  the
unconditional  beneficial  owner of the Shares,  free and clear of any  security
interest,  claim  or  charge.  The  Shares  are  registered  in the  name of the
undersigned,  no other  person or entity has an  interest  in the Shares and the
undersigned has fully right, power and authority to sell,  pledge,  transfer and
deliver the Shares.


         2. The  Shares or any other  such  shares  owned or  controlled  by the
undersigned  (i)  have  not  been  assigned,   transferred,   donated,  pledged,
encumbered  or the  subject of a put or call  option by the  undersigned  or any
other person or entity (ii) will be deposited in the account of the  undersigned
with DLJ in fully  negotiable  form,  and (iii) for the period of the agreement,
will not be sold, assigned,  transferred,  donated,  pledged,  encumbered or the
subject of a put or call option by the undersigned or any other person or entity
without the prior written consent of a principal of DLJ; provided, however, such
requirement shall not apply to sales of the Shares through DLJ, or the pledge of
the Shares to DLJ as provided in the agreement.


         3. All of the Information set forth by the undersigned in the Form 144,
Rule 144 Questionnaire and representation  letter,  copies of which are attached
and made a part hereof,  is accurate and complete and should any change or event
occur  which  would  render  the  information  Inaccurate  or  Incomplete,   the
undersigned will immediately notify DLJ of such change or event.


         4.  The  margin  credit   arrangement   referred  to  herein  shall  be
supplemental  and in addition to all the terms and  conditions  of the  Customer
Agreement between the undersigned and DLJ which the undersigned  acknowledges he
has read, understood, and executed and which remains in full force and effect.


         5. It is understood  that the minimum margin  required to be maintained
by the  undersigned  for the Shares is 40% of the  current  market  value of the
Shares as  determined  on a day by day basis or $3.00 per  share,  whichever  is
greater. It is further understood that such minimum maintenance  requirement may
be changed by DLJ at any time.

                                       1

6. Should it become necessary to sell any of the Shares or to satisfy a margin deficiency, the undersigned agrees fully to cooperate with DLJ, including the furnishing of information and completion of forms and instruments necessary to effect the sale. In addition, DLJ shall be authorized to sign a properly completed Form 144 in the name of and on behalf of the undersigned. Capitalized terms that are used herein but not otherwise defined shall have the meanings ascribed to such terms in Control or Restricted (Rule 144) Stock Borrower's Agreement between the undersigned and DLJ of even date herewith. 7. It is agreed that in the event the undersigned fails to satisfy a margin deficiency, DLJ is hereby authorized to liquidate at it discretion sufficient shares of this security held in the undersigned's account to satisfy the margin deficiency. 8. The undersigned will not take any action that would impair the salability of the Shares or omit to take any action necessary to avoid such impairment. The undersigned further agrees to indemnify and hold harmless DLJ and its officers and employees from any loss, liability, claim, damage or expense, including any legal expense, to which DLJ and its officers and employees may become the subject as a result of any untrue statement or omission in any document furnished to DLJ by the undersigned or breach of this agreement by the undersigned. 9. The failure by DLJ to object to any act or omission on the part of the undersigned which is in contravention of any provision of this agreement, shall not constitute a waiver of any of the rights of DLJ under this agreement or otherwise. 10. The undersigned represents that he has sufficient collateral or cash to meet any margin calls which might result form a margin deficiency or from the subsequent unavailability of Rule 144 and that he will promptly advise DLJ should he become aware of any circumstances indicating that Rule 144 is no longer available with respect to the shares pledged. 11. DLJ agrees that the interest rate to be charged shall be 3.00% above the Pershing Base Lending Rate, as described in the attached "Disclosure Statement." 2

12. This agreement shall remain in full force and effect until it is either (i) terminated by DLJ, or (ii) terminated by the undersigned with the consent of DLJ. However, all representations, warranties and indemnities provided by the undersigned hereunder shall survive the termination of this agreement. /s/Judith Segall ------------------------------- (Signature) Judith Segall ------------------------------- (Name) ------------------------------- (Date) ------------------------------- (Account Number) Joint Account ------------------------------- (Signature) ------------------------------- (Name) ------------------------------- (Date) 3