As filed with the Securities and Exchange Commission on August 25, 2000

                                                  Registration No. 333-44092
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 AMENDMENT NO. 1
                                       TO
                                    FORM S-3
                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933
                           --------------------------
                                  BIOTIME, INC.
               (Exact name of Registrant as specified in charter)
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             California                                     94-3127919
   (State or other jurisdiction                           (I.R.S. Employer
   incorporation or organization)                      Identification Number)

                                         Paul E. Segall, Chief Executive Officer
       935 Pardee Street                            BioTime, Inc.
    Berkeley, California 94710                   935 Pardee Street
        (510) 845-9535                       Berkeley, California 94710
 (Address, including zip code,                    (510) 845-9535
 and telephone number, including area      (Name, address, including zip code,
 code, of Registrant's principal             and telephone number, including
 executive offices)                          area code, of agent for service)

                            -------------------------
 Copies of all communications, including all communications sent to the agent
                        for service, should be sent to:
                             RICHARD S. SOROKO, ESQ.
               Lippenberger, Thompson, Welch, Soroko & Gilbert LLP
                        250 Montgomery Street, Suite 500
                         San Francisco, California 94104
                               Tel. (415) 421-5300
                            -------------------------

Approximate  date of  commencement  of proposed  sale to the public:  As soon as
practicable after this Registration Statement becomes effective.

If the only securities  being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, please check the following box. |_|

If any of the  securities  being  registered on this form are to be offered on a
delayed or continuous  basis pursuant to Rule 415 of the Securities Act of 1933,
other than  securities  offered  only in  connection  with  dividend or interest
reinvestment plans, check the following box. |X|

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the  Securities  Act  registration  statement  number of the  earlier  effective
registration statement for the same offering. |_|

If this Form is a  post-effective  amendment filed pursuant to Rule 462(c) under
the  Securities  Act,  check  the  following  box and  list the  Securities  Act
registration  statement number of the earlier effective  registration  statement
for the same offering. |_|

If delivery  of the  prospectus  is  expected  to be made  pursuant to Rule 434,
please check the following box. |_|

The Registrant hereby amends this  Registration  Statement on such date or dates
as may be necessary to delay its Effective Date until the Registrant  shall file
a further amendment which specifically  states that this Registration  Statement
shall  thereafter  become  effective  in  accordance  with  Section  8(a) of the
Securities  Act of 1933,  or  until  the  Registration  Statement  shall  become
effective on such date as the Commission,  acting pursuant to said Section 8(a),
may determine.

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                                     PART II

INFORMATION NOT REQUIRED IN PROSPECTUS


Item 14.  Other Expenses of Issuance and Distribution

     The estimated  expenses of the  Registrant in connection  with the issuance
and distribution of the securities being registered hereby are as follows:

Registration Fee-Securities and Exchange Commission...................$1,285.24
Accounting Fees......................................................$25,000.00
Legal Fees...........................................................$10,000.00
Miscellaneous Expenses................................................$1,714.76
                                                                       --------
                Total................................................$38,000.00
                                                                      =========
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Item 15.  Indemnification of Directors and Officers.

          Section   317   of   the   California    Corporations   Code   permits
indemnification   of  directors,   officers,   employees  and  other  agents  of
corporations  under certain  conditions and subject to certain  limitations.  In
addition,  Section  204(a)(10)  of the  California  Corporations  Code permits a
corporation to provide,  in its articles of incorporation,  that directors shall
not have liability to the corporation or its  shareholders  for monetary damages
for breach of fiduciary duty, subject to certain prescribed exceptions.  Article
Four of the Articles of Incorporation of the Registrant  contains provisions for
the  indemnification of directors,  officers,  employees and other agents within
the limitations  permitted by Section 317 and for the limitation on the personal
liability  of  directors  permitted  by  Section  204(b)(10),   subject  to  the
exceptions required thereby.

                                      II-1

Item 16. Exhibits and Financial Statement Schedules. Exhibit Numbers Description 4.1 Warrant Agreement* 4.2 Form of Warrant* 5 Opinion of Counsel* 23 Consent of Deloitte & Touche LLP* *Previously filed. Item 17. Undertakings. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers, and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by final adjudication of such issue. The undersigned registrant hereby undertakes: (1) To file during any period in which offers or sales are made, a post-effective amendment to this registration statement: (i) To include any prospectus required by section 10(a)(3) of the Securities Act of 1933; (ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate represent a fundamental change in the information set forth in the registration statement; (iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement. II-2

(2) That for the purpose of determining any liability under the Securities Act of 1933, each post- effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. (3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. The undersigned registrant hereby undertakes that, for the purposes of determining any liability under the Securities Act of 1922, each filing of the registrant's annual report pursuant to section 13(a) or section 15(d) of the Securities Exchange Act of 1934 that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. The undersigned undertakes that: (1) For the purposes of determining any liability under the Securities Act of 1933, the information omitted from the form of prospectus filed as part of this registration statement in reliance upon Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b)(1) or (4) or 497(h) under the Securities Act shall be deemed to be part of this registration statement as of the time it was declared effective. (2) For the purposes of determining any liability under the Securities Act of 1933, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the bona fide offering thereof. II-3

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant has duly caused this Amendment to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Berkeley, State of California on August 23, 2000. BIOTIME, INC. By Paul Segall ---------------------------------- Paul Segall, Chief Executive Officer Pursuant to the requirements of the Securities Act of 1933, this Amendment to the Registration Statement has been signed below by the following persons in the capacities and on the dates indicated. Signature Title Date --------- ----- ---- /s/Paul E. Segall Chairman, Chief Executive Officer and August 23, 2000 - ---------------------- Director (Principal Executive Officer) Paul E. Segall, Ph.D. /s/Ronald S. Barkin President and Director August 23, 2000 - ---------------------- Ronald S. Barkin /s/Harold D. Waitz Vice President and Director August 23, 2000 - ---------------------- Harold D. Waitz, Ph.D. /s/Hal Sternberg Vice President and Director August 23, 2000 - ---------------------- Hal Sternberg, Ph.D. /s/Victoria Bellport Chief Financial Officer and August 23, 2000 - ---------------------- Director (Principal Financial and Victoria Bellport Accounting Officer) /s/Judith Segall Vice President, Corporate Secretary August 23, 2000 - ---------------------- and Director Judith Segall - ---------------------- Director August__, 2000 Jeffrey B. Nickel - ---------------------- Director August__, 2000 Milton H. Dresner II-4

EXHIBIT INDEX Exhibit Numbers Description 4.1 Warrant Agreement* 4.2 Form of Warrant * 5 Opinion of Counsel* 23 Consent of Deloitte & Touche LLP* *Previously filed.